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Chanca Piedra 500mg (90Capsules)

USD $25.97

Chanca Piedra

contains Phyllanthus niruri which is traditionally used in Ayurveda as a diuretic (Mutrala) to help relieve mild urinary tract infections.

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Product Code: HI2179 Categories: , Brand:

Product Description

AOR Chanca Piedra

PN also known as Chanca Piedra, has become well
known for its effectiveness in treating several conditions including:
urogenital conditions, gallstones and kidney stones, liver toxicity,
viruses like hepatitis B, and possibly even high blood pressure and
malaria.

A.O.R Advanced Orthomolecular Research Brand -AOR brand

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NPN (what’s this?) Product Code Size Per Capsule Vegetarian
80025537 AOR04326 90 Vegi-Caps 500 mg Vegetarian
Supplement Facts
Serving Size: 1 Capsule Amount Per Serving
Phyllanthus niruri extract (10:1) 500 mg
Non-medicinal ingredients: none. Capsule: hypromellose.

Note: Product appearance, odor and taste may vary from lot to lot due to the use of natural ingredients

AOR Guarantees:
that no ingredients not listed on the label have been added to the
product. Contains no wheat, gluten, nuts, peanuts, sesame seeds,
sulphites, mustard, dairy, soy, eggs, fish, shellfish or any animal
byproduct.

Adult Dosage: Take 1 capsule per day, or as directed by a qualified health practitioner.

Cautions: Consult a health care practitioner prior to use if you have diabetes, or if symptoms persist or worsen.

Pregnancy/Nursing: Consult a health care practitioner prior to use.

Source:
Phyllanthus niruri extract

Main Indications:

  • Anti-viral
  • Liver protective
  • Gall stones and kidney stones

Research

Background Information

Phyllanthus niruri (PN)
Chanca Piedra is the Spanish common name for the herb Phyllanthus niruri/amarus.
PN is a perennial herb common in hot central and southern areas of the
Indian Subcontinent. It also grows in China, and numerous tropical
locations including the Philippines, Cuba, and the Amazon rainforest.
This plant has been used for over 2000 years to treat a wide variety of
conditions and diseases including influenza, tumors, diabetes,
jaundice, gallstones, kidney stones and upset stomachs. More recently,
PN has become well known for its effectiveness in treating liver
toxicity, viruses like hepatitis B, and possibly even high blood
pressure and malaria. The extract of the leaves of PN contains various
biologically active chemicals that have been associated with a wide
variety of effects. Many different classes of organic compounds of
medicinal interest have been reported, including alkaloids, flavonoids,
lactones, steroids, terpenoids, lignans, tannins, with lignans,
triterpenes, alkaloids, and tannins generally being the most abundant.
Although this sounds very complicated, it is this diverse mix of
chemicals that gives PN the ability to treat a wide range of problems.

Research

Antiviral Properties
One of the most impressive applications of PN is in the treatment of
certain viruses, particularly hepatitis B. Hepatitis B is a virus that
affects the liver, causing inflammation and jaundice, possibly leading
to liver cirrhosis, cancer, or even death. Many people will clear the
infection on their own after a few weeks, but others, especially
children, will be unable to eliminate the virus, and will suffer from
chronic hepatitis. The chronic form of the virus may manifest as an
asymptomatic “carrier state” or may be associated with constant liver
inflammation. Infection with hepatitis B is always associated with the
presence of a certain surface antigen on the liver cells called Hep B
Surface Antigen or HBsAg. Both In-vitro and In-vivo studies have
reported that PN exhibits marked anti-HBsAg activity on the surface of
liver cells. In another study, 37 patients with chronic viral hepatitis B
were treated with a daily dose of 600mg of PN for 30 days. 59% of the
patients showed a complete loss of HBsAg two weeks after the end of the
treatment. Furthermore, none of the cases followed for up to 9 months
had any symptoms of HBsAg. The authors postulated that PN may inhibit
proliferation of the virus by inhibiting replication of the genetic
material of the virus.

The extremely impressive anti-viral properties of PN are demonstrated in
another clinical trial involving 160 children (age 1-12 years) with
infective hepatitis. The authors reported that the virus was “cured” in
101 of the children, with the other 59 being dropouts. Normal appetite
was seen in 7 days, while jaundice, hepatic tenderness, and other
symptoms of hepatitis B all disappeared completely within 5 weeks.

Hepatitis B is not the only virus that can potentially be treated by
PN. Recent studies have indicated that PN may also be beneficial in the
treatment of Human Immunodeficiency Virus (HIV). Studies have shown that
PN extract is able to inhibit replication of the HIV virus by
inhibiting certain enzymes (such as HIV type-1 reverse transcriptase)
essential for replication of the virus. Other evidence suggests that the
HIV inhibiting ability of PN extract is related to its alkaloid
components.

Liver Protection
In addition to protecting the liver from viruses like hepatitis B, PN
has also been documented to protect the liver from damage by a variety
of chemical liver toxins. Furthermore, a protein component of PN has
been shown to protect liver tissues from oxidative stress in mice.

Kidney Stones and Gallstones
Another well documented application of PN extract is for the treatment
of kidney and gall stones. Kidney stones are one of the most painful and
common urinary tract problems, and it is reported that over 600, 000
patients are treated for gallstones in the U.S. alone each year. In
South America, PN is commonly known as “Chanca Piedre” which in the
local dialect of Spanish means, “to break stone”. The ability of PN
extract to inhibit the growth of kidney stones has been clearly
demonstrated in both animals and humans. PN has been used to treat gall
bladder infections in South America, and is often taken in the form of
tea. PN has also been used in Germany and France to treat gall bladder
and kidney stones with over a 95% success rate within 1-2 weeks of
treatment. A study examining calcium excretion in 69 individuals with
past incidences of kidney stones has shown that PN extract significantly
decreases calcium levels in the urine. Furthermore, PN has been
demonstrated to effectively inhibit the internalization of calcium
oxalate crystals, which are the building blocks of kidney stones. Yet
another study found that treatment with PN following shock wave therapy
for kidney stones improved the outcome of the treatment. A greater
proportion of patients taking PN were found to be stone-free following
treatment, and were less likely to require additional shock wave
therapy.

In addition to its ability to inhibit crystal internalization, PN’s
ability to treat kidney stones may be further enhanced by the powerful
spasmolytic, or muscle relaxant, activity of one of the constituents of
PN, phyllanthin. Relaxation of the smooth muscle of the kidney tubules
and ureter may help to expel stones.

Malaria
Although it has yet to be tested in humans, in vitro and in vivo studies
with mice have indicated that PN shows potential as an anti-malaria
agent. In vitro studies have shown that PN extracts are capable of
inhibiting growth of the parasite causing malaria by 50-100%.
Furthermore, when mice were given doses of 500mg/kg of PN extracts over
the course of 4 days, the incidence of parasitic infection was
suppressed by up to 73%.

In Conclusion
Extracts of PN have a wide variety of therapeutic applications. Results
of animal studies and human clinical trials have provided compelling
evidence of PN’s effectiveness in the treatment of hepatitis B and
kidney stones. Other beneficial effects of PN are still being
investigated, but the potential of its use in the treatment of HIV,
Malaria, and other disorders such as diabetes and hypertension are
promising.
 

Market Trends

Persons suffering with painful gallbladder issues
often search for ways to help themselves to cope with the problem.
Unfortunately, the end result is often the removal of the gallbladder,
although some supplements including Gold Coin Grass and Chanca Piedra
can help to effectively break down the stones.

AOR Advantage

References

Bagalkotkar G, Sagineedu SR, Saad MS,
Stanslas J. “Phytochemicals from Phyllanthis niuri Linn. And their
pharmacological properties: a review.” Journal of Pharmacy and
Pharmacology 2006; 58: 1559-70.

Calixto JB, Santos ARS, Filho VC, Yunes RS. “A Review of the
plants of the genus Phyllanthus: their chemistry, pharmacology and
therapeutic potential.” Medicinal Research Reviews 1998; 18(4): 225-58.


Campos AH, Schor N. “Phyllanthus niruri inhibits calcium oxalate
endocytosis by renal tubular cells: its role in urolithiasis.” Nephron
1999; 81(4): 393-7.

Campos AH, Schor N. “Phyllanthus niruri inhibits calcium oxalate
endocytosis by renal tubular cells: its role in urolithiasis.” Nephron
1999; 81(4): 393-7.

Freitas AM, Schor N, Boim MA. “The effect of Phyllanthus niruri
on urinary inhibitors of calcium oxalate crystallization and other
factors associated with renal stone formation.” BJU Int 2002 Jun; 89(9):
829-34.

Mehrotra R, Rawat S, Kulshreshtha DK, Patnaik GK, Dhawan BN. “In
vitro studies on the effect of certain natural products against
hepatitis B virus.” Indian J Med Res 1990 Apr; 92: 133-8.

Micali S, sighinolfi MC, Celia A, De Stefani S, Grande M, Cicero
AF, Bianchi G. “Can Phyllanthus niruri affect the efficacy of
extracorporeal shock wave lithotripsy for renal stones? A randomized,
prospective, long-term study.” Journal of Urology 2006; 176(3):1020-2.

Naik AD, Juvekar AR. Effects of alkaloidal extract of Phyllanthus
niruri on HIV replication.” Indian Journal of Medical Science; 57(9):
387-93

Ogata T, Higuchi H, Mochida S, Matsumoto H, Kato A, Endo T, Kaji
A, Kaji H. “HIV-1 reverse transcriptase inhibitor from Phyllanthus
niruri.” AIDS Res Hum Retroviruses 1992 Nov; 8(11): 1937-44.

Syamasundar KV, Singh B, Thakur RS, Husain A, Kiso Y, Hikino H.
“Antihepatotoxic principles of Phyllanthus niruri herbs.” J
Ethnopharmacol 1985 Sep; 14(1): 41-4.

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