Imagine knowing when to start eating-and exactly when to stop-without guilt or rigid calorie counting. Even better, picture reaching the weight you’re meant to be… without starvation or crazy diets.
It might sound too good to be true. But it’s not… in fact, your body has evolved to function this way naturally on its own. The only thing it needs to maintain this foolproof routine is balance-and more specifically, balanced levels of the hunger hormone leptin.
Leptin, along with insulin, is responsible for controlling your body’s energy storage by telling your brain how much ‘ls-and whether you need more of it, less of it, or whether you’re just right.1-2 The process works like this: Excess calories are stored as fat in the body as a reserve for future energy requirements or insulation from the cold; the fat storage cells produce leptin, which in turn tells your hypothalamus to stop sending hunger signals.3 Less leptin, on the other hand, prompts more hunger… more eating… and as a result of more calories being consumed, extra energy is available for daily activities and replenishment of the stored fat.
This critical chain of command regulates the most basic and effective form of appetite control you can find-so it shouldn’t surprise you that there are serious consequences when your body’s natural balance is compromised. And if you’ve been struggling to maintain your weight without success, chances are good that your eating habits and metabolic energy balance have been compromised due to a problem known as leptin resistance-a condition in which your body becomes desensitized to leptin’s signaling. Just as repeated insulin surges caused by high blood sugar lead to insulin resistance, one too many leptin surges mean its messages to your hypothalamus no longer get through.4-5
The result: An out-of-control appetite and too much caloric intake, which leads to weight gain and obesity, and possibly a whole host of other serious conditions-including the metabolic syndrome, type 2 diabetes, heart disease, high blood pressure, osteoporosis, autoimmune diseases and increased inflammation, to name a few.6-17
Obviously, getting more leptin isn’t the answer-a fact demonstrated by some of the earliest research on this hunger hormone. In leptin-resistant human subjects, extra doses offer little help in the fight against fat.18 What you need is a way to prevent surges and boost your body’s leptin receptivity… and luckily, there are targeted supplements designed to do just that.19-20
LeptinX is a new proprietary formula from Vitamin Research Products that’s specifically designed to curb your appetite and boost fat loss by modulating your body’s levels of both leptin and adiponectin-another crucial fat-regulating hormone. In fact, the breakthrough blend of ingredients in LeptinX is clinically shown to deliver better results than diet or exercise alone-in the form of fat loss, weight reduction and smaller waist size -safely, naturally and after just eight weeks of use.
References:
1. Harris RB. Leptin-much more than a satiety signal. Annu Rev Nutr. 2000;20:45-75.
2. Rosenbaum.M and Leibel, R.L. Leptin: A Molecule Integrating Somatic Energy Stores, Energy Expenditure and Fertility TEM. 1998;9(3).
3. Houseknecht KL, Baile CA, Matteri RL, Spurlock ME The biology of leptin: a review J Anim Sci. 1998 May;76(5):1405-2.
4. Mueller WM. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology. 1998;139(2):551-58.
5. Agus MS. Dietary composition and physiologic adaptations to energy restriction. American Journal of Clinical Nutrition. 2000;71(4):901-07.
6. Barouch, L. A. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 2003;108(6):754-59.
7. Galletti F, D’Elia L, Barba G, Siani A, Cappuccio FP, Farinaro E, Iacone R, Russo O, De Palma D, Ippolito R, Strazzullo P. High circulating leptin levels are associated with greater risk of hypertension in men independently of body mass index and insulin resistance: results of an 8-year follow-up study. J Clin Endocrin Metabol. 2008;93:3922-3926.
8. Parhami F. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circulation Research. 2001;88(9):954-60.
9. Wallace AM. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2001;104:3052-56.
10. Harris, Ruth B. S. Leptin-much more than a satiety signal. Annual Review of Nutrition. 2000, Vol. 20, 45-75
11. Lin C-Y, Higginbotham DA, Judd RL & White BD. Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. American Journal of Physiology. Endocrinology and Metabolism. 2002;282: E1084-E1091.
12. Hedbacker K, et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab. 2010; DOI:10.1016/j.cmet.2009.11.007.
13. Ducy P. The osteoblast: A sophisticated fibroblast under central surveillance. Science. 2000;289:1502-04.
14. Karsenty, G. The Central Regulation of Bone Remodeling. Trends in Endocrinology and Metabolism. 2000;11(10):437-439.
15. Sanna V. Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. Journal of Clinical Investigation. 2003;111:241-50.
16. Matarese G. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes. 2002;51(5):1356-61.
17. La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J. Mol. Med. 2004;82:4-11.
18. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996 Feb 1;334(5):292-5.
19. Ainslie DA. Short-term, high-fat diets lower circulating leptin concentrations in rats. American Journal of Clinical Nutrition 2000;71:438-42.
20. Rosedale R, Westman EC. Clinical Experience of a Diet Designed to Reduce Aging, Journal of Applied Research. Accepted for publication.
